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You must be looking at running Dynamics with Microsoft CRM is what it sounds like? That's probably much smoother then what I'm running. We have to write all of our own CRM integration customizations in order to get updates from the ERP into the CRM and back the other way.
Two of the big benefits to running Dynamics are the multi-dimensional pricing capabilities and the Order Pipelines that can be exposed from your website. This will allow your eCommerce sites to write orders right into the Accounting System at various price levels based on your customers price structure. You'll want to understand if this still uses Commerce Server to enable this feature because if it does there's an additional license fee for Commerce Server.
It has also stood the test of time w/o a support contract. When we put this ERP in we thought that we might be able to reasonably get a 15 year life cycle out of it and we're at 9 years now. We've also done 2 major upgrades to the original version on our own, which is how we got to 6.0. At the time the support contract was just about 40K per year. We decided to forgo that and so far it's saved us roughly 360K.
My only desire is that it would have a more complete integration like NetSuite or similar. But what do I want for free? I have just hired a full time IT person for my little operation, and he is a big open source enthusiast and is making plans for writing the integrations we need. We will then post them for public use on the sugarforge website. This could take 2 months or 2 years, so don't hold your breath.