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Another advantage is that you can often agree a contract duration be it 6mths or 2 years. As long as you maintain your traffic and the bids don't tank that is fair security.
Obviously you need to be confident that the tier2 is going to still be around and is in good standing two years down the road. In that sense Google perhaps seems more of a sure thing, its not going to go bust anytime soon. Then look at how they can play around with the percentage share publishers get from the clicks and how it can go from great to almost nothing.
I think with the right deal, tier2 engines can be very lucrative and very stable income.