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<img border="0" onclick="document.location.href='/destinations/default.aspx';" onmouseout="removeselect('visible')" onmouseover="this.style.cursor='pointer';dropdownmenu(this, event, 'anylinkmenu1')" src="/images/home_nav.gif" width="152" height="64" />
Thanks
So, for your case:
<a href="/destinations/default.aspx"><img border="0" onmouseout="removeselect('visible')" style="cursor: pointer;" onmouseover="dropdownmenu(this, event, 'anylinkmenu1')" src="/images/home_nav.gif" width="152" height="64" /></a>
might work better. Also note that I moved your javascript code to set the style of the <img> to cursor: pointer; into an actual style--there's no need whatsoever for this to be done through javascript unless you actually want people with javascript disabled to not see the cursor you've picked.
...its worked on all the spider tools i've used...
I'd be very surprised if it was SE friendly. Are your spider tools SE spider simulators? For your link to be picked up the a SE, the SE spider would have to parse JS (albeit a very little bit), and as far as I'm aware, they don't?
Can anyone confirm this?
I'd certainly go with WesleyC's recommendation and use the <a> element.