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As for tables... someone here surely has a better answer, as i rarely ever use tables... but here it goes, assuming you're talking about layout with tables:
Browsers need to figure out what a table's structure looks like before it can load, which can cause a lot of confusion. The fact that the beginning of your "wrapper" table in a layout lies atop the code, and the end of the table lies at the bottom of the code, is obviously counter-productive to having any kind of load "order" at all.. laying out tabled designs builds the page from the outside in, and not from the top down, which is how browsers intuitively read code.