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If it's for Google's "keyword in domain" boost then I wouldn't worry; Google doesn't put significant weight on the domain.
If it's to encourage other Webmasters to use your favourite words when they link to you, eg. "large pie from pie-apple.com" then yes it would help. (In that example, the domain encouraged the webmaster to use apple in the link text.) Still, it's not something I'd worry about too much when choosing a domain.