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I have extensive vbscript knowledge and a bit of Visual Basic programming experience. Discussion regarding how to get the initial interface up (open a channel to the MQSeries queue and send a message, and receive a message would go a long way to solving my problems).
Once the user submits the form, you could write that information to a Physical File. Then, using either a trigger or better yet a remote command (call a batch file on the server which can FTP a command to the 400) you can call the RPG program which will process the data posted to the PF.
Either way, you are right, it's more complicated than a simple read/write to the DB.