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DW seems to ignore the whitespace completely in the "from" string (eg. changing 1.00 to "1. 00"!)
I don't know if DW supports regex - but I realised that it was just as easy for me to do the replace with Notepad before I started off on that path.
If the files are too big maybe try Wordpad or Word (or whatever editor you want really).
Word's pretty good at that sort of stuff - you can replace paragraph marks etc too (look at special characters in the help). So, for example replacing " ^p" with "^p" replaces the whitespace at the end of each line only. Run it repeatedly and all trailing whitespace is gone (but then I think they may have a macro do that - you get my drift anyway).