This is something I have noticed quite a lot recently - my browser becomes unresponsive after it has been open a while - in addition to this my OS is becoming unresponsive.
Now my first though was that my machine was getting a bit old and the Windows updates were killing performance - but no, a bit of investigation led me to looking at memory - it was all being used by Google Chrome.
No I use chrome and keep lots of tabs open - and have loads of bookmark folders to fast open a lot of tabs. Watching memory usage by chrome I see it steadily increase over my working day - 1Gb, 2Gb, 3Gb .... I know this didn't use to happen 3-4 years ago with the same number of tabs, so I can only think that the new javascript framework (angular.js, react.js etc) based sites are eating memory with their polling, notifications and listeners to the point that the browser becomes unresponsive. I get loads of 'do you want to wait for this page to respond' pop-ups in Chrome too.
I need to do some investigation to see whether this issue is Chrome specific or whether other browsers are being as badly affected - but has anyone else seen similar behaviour recently. (I know it is probably heretical to say anything against javascript frameworks at the moment)