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Warning: require_once(System.php) [function.require-once]: failed to open stream: No such file or directory in /var/www/vhosts/site.com/httpdocs/x.php on line 2
Fatal error: require_once() [function.require]: Failed opening required 'System.php' (include_path='.:/usr/share/psa-pear/') in /var/www/vhosts/site.com/httpdocs/x.php on line 2
php_admin_value open_basedir "/var/www/vhosts/site.com/httpdocs/:/tmp/:/usr/share/pear"
php_admin_value include_path ".:/usr/share/pear"
...then I am thinking it should have said something about permission, but it simply says it can't find it.