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If you use the following structure user@domain the server is getting in an authentication loop or something, and will continue to produce like 1500 401 errors per second till your disk is full. After restarting the service you can get out of the loop.
How do I prevent for now Chrome brouwsers to be able to login? Block the browser?
We're investigating this issue and will announce updates in the help forum when we have more information.
I don't know enough about configuring IIS to block Chrome browsers, though.
What version of IIS, and OS?