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This is actually an interesting question and I'm interested in hearing other people's ideas.
I used to optimize for 1 keyword per page. Lately, following Brett's advise, I've been throwing in more keywords per page. I'm consciously optimizing for 5 keywords per page now, plus trying to work other possible kw combos into the text of the pages.
However, I recall someone mentioning that they optimize for a few dozen keywords per page.
I've been trying to use a variety on different sites to try to determine what works best.