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Now, what if the nameserver for the site is on an ip associated with an american company, but it points to a uk ip address (where the site is actually hosted)?
Will google.co.uk see this .com site as a "site from the uk" or a site NOT from the uk?
Do you see this as a problem? The only difference from google's POV is that searchers in the UK will find your site with the option "Show sites from the UK" (or whatever) as well, which may bring a few more hits.
As long as your UK IP is correctly identified, you should be OK, although you might be better served by a .uk domain name if you are mostly targeting UK visitors.