Forum Moderators: phranque
The main problem that I found was that as the sites are written in Javascript the content is practically invisible to search engine spiders - a bit like webmaster world at the moment ;) This may or may not be a concern to you. You could probably build something similar with Flash if it's not. There may also be problems with accessibility as well, you may need to check that.
I've seen a couple of example ecommerce sites using Ajax and no doubt about it they do look very good: pick up the item you want with your mouse and drop it straight into the basket.