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The biggest and baddest of them seems to be Horde-Imp. It seems that many universities use it for their webmail interface (my own uni included). It does seem fairly complex though.
A solution that seems slightly simpler, although not as feature-rich, seems to be squirrelmail. I've got no experience with this, although many ISP's offer it as their webmail solution.
There is another one called neomail, but I haven't found out much about it yet.
I haven't installed any of them, this is just from what I've learned surfing various websites. I don't know how easy it is to add new users or how this would need to tie in with your ISP. From what I can tell, all the above scripts are free.
If you find you already have them take em off or ask your host to do so ..this will help prevent you being used for spam relays ..and waking up to find some group from Brazil or Indonesia "Ownz U"
Also, it surprises me that so many educational institutions are using it; maybe their techies have just secured it enough to be able to use it without getting 'owned' :-)
Does anyone have any other (more secure) suggestions?