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The problem with the site I work for is getting repeat advertisers, we have a high volume of traffic and can offer high volumes of impressions however our readership is so finicky that it rarely clicks on the ads and CTR is extremely low.
This doesnt entice clients to renew their ads as really all they're after is referals, it doesnt matter how many impressions they've had.
The questions now are is anybody else suffering from this "useless reader" syndrome and what are the solutions? Any forms of alternative advertising for readers that ignore ads?
Network CPM campaigns often do okay ... providing I dont get a flood of complaints about crappy smilie ads.
Listen to feedback when you make the changes, it may be better to have a site with 1000 readers with only 1% clicking on the ads, opposed to to 100 readers where 5% click on the ads.
... or charge $1 per month for "full membership" and worry less about the ads.
aside from that, I'd say that rotating banners, ad colors and better placement is the best thing to try.