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Ones I have had good succes with:
OnResponse [onresponse.com] Decent number of offers, usually reply to emails, very few (delayed) payment problems.
WebSponsors [websponsors.com] Many offers, support unresponsive at times (haven't tried lately), not the quickest payments.
Directleads [directleads.com] Decent number of offers, excellent support, a few (delayed and non-paying advertisers) payment problems.
* note the above three aggregate advertising campaigns - the campaigns usually expire after a certain date, amount of leads, or amount of clicks. These are primarily lead based networks.
Ones I have had mediocre success with:
LinkShare [linkshare.com] Lots of merchants, but payments not combined. Support is there, but often inaccurate or no follow-ups. Serious accounting and payment problems.
BeFree/Reporting.net [reporting.net] Good number of merchants, payments not combined. Support usually non-existant. Payment problems with many merchants.
<disclaimer> The above comments are from my personal experience, one man's trial of each network. As always, your mileage may vary.
Other networks I haven't used much:
CyberBounty [cyberbounty.com] Similar to the first three I listed, but usually not as many offers.
SponsorShips [sponsorships.net] Also similar to the first three, but has some nice pre-coded stuff for CPC ad rotation in what they call a sponsor box. Recently, they changed their terms to only paying you after the advertiser paid them - proceed with caution.
Networks I haven't used at all:
ClickTrade [clicktrade.com] - would love to hear someone's experience with this network.
ClickXChange [clickxchange.com] I have joined this program, but their interface is difficult to navigate to find good topical merchants. Many CPC advertisers, though. Anyone use this one?
These are the main affiliate options that I am aware of. Experience with any of these or any others welcome and appreciated.