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If you have a site getting low CTR with adsense AND low EPC, switch to YPN. "Low" is a relative term, but I'm talking about less than 3% CTR and less than 10¢ EPC.
I've switched 2 of my sites that fall into that category to YPN and the results are very encouraging. YPN is paying a lot more per click - in my case about 6X as much as adsense! And the CTR is not all the much lower. So the net result is a bigger payday from those sites. Try it.