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I (personally) do not believe that Flash makes for a good full interface environment, but perhaps Flex addresses the shortcomings Flash has/had in this area....
Good thing about flex is that you can build amazing applications in a very short time period.
IE, i did build a search frontend with the Amazon Soap service within 15 minutes, and less as 20 lines of code.
Beware of the high license costs, about 20k for a dual cpu. Good thing is that you can download a developer versions that keeps working :)