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New hope?

         

tangor

12:22 am on Mar 26, 2020 (gmt 0)

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(Reuters) - As the United States works overtime to screen thousands for the novel coronavirus, a new blood test offers the chance to find out who may have immunity - a potential game changer in the battle to contain infections and get the economy back on track.


[reuters.com...]

lucy24

12:43 am on Mar 26, 2020 (gmt 0)

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I struggled to reconcile “works overtime to screen thousands” with (later paragraph) “sometimes hard-to-come-by diagnostic tests” ... until I realized that we have a population in the hundreds of millions. Yeah, screening thousands is definitely a stretch.

Mark_A

10:32 am on Mar 26, 2020 (gmt 0)

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I read that in California health workers are relying on crowdfunding to buy adequate PPE.

lammert

11:35 am on Mar 26, 2020 (gmt 0)

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I also read (see source below) that in California there are warnings to be cautious sending money to crowdfunding campaigns for PPE because it can be a scam. A list of public initiatives in California [latimes.com] and questions and answers about them was published in the Los Angeles Times.
Q: Should I donate cash to crowdsourced or other donor campaigns I’m seeing online?
Be cautious. Although there are some legitimate campaigns organized by well-meaning people on crowdfunding sites like GoFundMe, potential scams await as well.

not2easy

1:19 pm on Mar 26, 2020 (gmt 0)

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It has become "where there's a way, there's a will" rather than "where there's a will, there's a way". :(

tangor

4:27 pm on Mar 26, 2020 (gmt 0)

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More new hope ... Alex Berensen, a NYT reporter tweeted this thread today:


1/ This is a remarkable turn from Neil Ferguson, who led the @imperialcollege authors who warned of 500,000 UK deaths - and who has now himself tested positive for #COVID; newscientist.com/article/223857…
2/ He now says both that the U.K. should have enough ICU beds and that the coronavirus will probably kill under 20,000 people in the U.K. - more than 1/2 of whom would have died by the end of the year in any case bc they were so old and sick.
3/ Essentially, what has happened is that estimates of the viruses transmissibility have increased - which implies that many more people have already gotten it than we realize - which in turn implies it is less dangerous.
4/ Ferguson now predicts that the epidemic in the U.K. will peak and subside within “two to three weeks” - last week’s paper said 18+ months of quarantine would be necessary. imperial.ac.uk/news/196477/j-…
5/ One last point here: Ferguson gives the lockdown credit, which is *interesting* - the UK only began ita lockdown 2 days ago, and the theory is that lockdowns take 2 weeks or more to work.
6/ Not surprisingly, this testimony has received no attention in the US - I found it only in UK papers. Team Apocalypse is not interested.


[threadreaderapp.com...]

lammert

5:17 pm on Mar 26, 2020 (gmt 0)

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@tangor, You once again post a selective piece of disinformation. The original article is in the New Scientist [newscientist.com].

This article is about the availability of ICU beds in the UK to manage the predicted peak in 2 to 3 weeks. But nowhere does it state that after that peak the problems are over. The article instead mentions the opposite, that suppression of transmission by broad testing is necessary for the coming 12 to 18 months, waiting for a vaccine to become available.
Ferguson said the current strategy was intended to keep transmission of the virus at low levels until a vaccine was available. Experts say that could take 12 to 18 months and Ferguson acknowledged it was impractical to keep the UK in lockdown for so long, especially because of the impact on the economy.

The UK government is aiming to relax restrictions on people’s movements only when the country has the ability to test more people for the virus, said Ferguson.

not2easy

7:18 pm on Mar 26, 2020 (gmt 0)

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Just a reminder, as posted in another thread on this topic - please stick to facts:

Please stick to the facts, and please use only authority sites to show examples of the claims. Authority sites only. No hear-say.

It's how we can all get through this by understanding the facts.

Thank you

tangor

8:33 pm on Mar 26, 2020 (gmt 0)

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I posted the tweets. No editorializing on my part. Just THE FACTS :)

See also a new hope:

[gov.uk...]

Read what I say, not what you think I said. :)

My brother (14 months younger than I, but in the 70's category as well) has this "respiratory disease" on top of the stroke he has been recovering from since 2011 in an assisted living care facility.

Believe me, I do not take any of this lightly.

At the same time I am not going to blindly panic.

It appears that the infection rates are a factor to 10 or more and MOST never become fully "ill" or at worst it's a week or two then gone. If that is taken into consideration the mortality rates change markedly, though those who have died won't know the difference, or their loved ones will feel any consolation.

blend27

11:18 pm on Apr 1, 2020 (gmt 0)

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Now that they 'Ramped Up' with millions and thousands of billions of tests, thank you dear leader...

and like John usually says:... And now this: [cnn.com...]

tangor

12:37 am on Apr 2, 2020 (gmt 0)

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Is it thousands,
Millions,
Or Billions?

Changing numbers for a commentary is ... interesting.

Could this be why the hysteria is on-going?

If adsense was calculated using the same magical numbers there'd be a different conversation going on.

buckworks

2:51 am on Apr 2, 2020 (gmt 0)

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Tangor, you missed the sarcasm.

tangor

4:45 am on Apr 2, 2020 (gmt 0)

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As did you. :)

tangor

1:52 am on Apr 5, 2020 (gmt 0)

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• Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro.
• A single treatment able to effect ∼5000-fold reduction in virus at 48h in cell culture.
• Ivermectin is FDA-approved for parasitic infections, and therefore has a potential for repurposing.
• Ivermectin is widely available, due to its inclusion on the WHO model list of essential medicines.

[sciencedirect.com...]

The Australians are doing their bit! Thumbs up!

not2easy

2:39 am on Apr 5, 2020 (gmt 0)

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Ivermectin is a drug commonly given for treatment of mange in cattle and dogs. Yes, cant wait to try it.

tangor

3:44 am on Apr 5, 2020 (gmt 0)

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Heh...

Did you miss the memo on the long chronicled use in humans since acceptance in 1981 and its inclusion on the WHO list of essential drugs?

[en.wikipedia.org...]

lucy24

3:47 am on Apr 5, 2020 (gmt 0)

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Ivermectin is a drug commonly given for treatment of mange in cattle and dogs.
! I thought that sounded familiar, but couldn't place it. You buy it at the farm-and-feed store in horse-sized tubes--that is, ahem, in tubes containing a horse dose--and give the size of a grain of rice (easier if diluted) to rats for most kinds of parasites. I think in horses it’s normally used for worming.

not2easy

4:11 am on Apr 5, 2020 (gmt 0)

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@lucy24 - that's the stuff. I see neighbors using it for goats, chickens, horses. It is fairly cheap to use and seems effective for parasites.

tangor

4:30 am on Apr 5, 2020 (gmt 0)

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Still missing the point. Was developed for HUMANS and found application in farming, too. There's any number of other drugs, primarily antibiotics, that are also used on animals, does not make them any less effective for the original purpose. Kudos to Australia for testing EVERYTHING against this pandemic. If it does kill it in 48 hours I'd be happy to have mange just to get it.

The thread is NEW HOPE, not Negativity on Parade...

lammert

10:15 am on Apr 5, 2020 (gmt 0)

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Thanks for sharing @tangor. Ivermectin (brand name Mectizan) is mass-produced by Merck/MSD in their factory in Haarlem in the Netherlands. 300 million doses are yearly donated free of charge [mectizan.org] by them to battle river blindness. A total of 120 million people each year are treated. So it is well known for human usage, safe, cheap to produce and a mass production facility exists.

But that doesn't say necessarily that it is the super drug to treat Covid-19, or that dosages safe for humans are effective at all against the virus. For that research is needed.

tangor

11:54 am on Apr 5, 2020 (gmt 0)

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Which the Australians are busy at. Research that is. :)

not2easy

1:24 pm on Apr 5, 2020 (gmt 0)

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For relevant research, Fujifilm [fujifilm.com] is researching an actual anti-viral medication that shows promise and has already been used in previous novel virus outbreaks.

Avigan, approved for manufacture and sale as an influenza antiviral drug in Japan, has a mechanism of action for selectively inhibiting RNA polymerase involved in influenza viral replication. Due to this mechanism, it is expected that Avigan may potentially have an antiviral effect on the new coronavirus as it is classified into the same type of single-stranded RNA virus as influenza, and its clinical application to treat COVID-19 is now under study.

Years ago, when film cameras were being replaced with digital equipment, Fuji aggressively sought to expand into related and unrelated fields such as Toyama Chemical to support the company's value. They are currently in phase III clinical trials.

TOKYO, March 31, 2020 - FUJIFILM Toyama Chemical Co., Ltd. (President: Junji Okada) has announced today the initiation of a phase III clinical trial to evaluate the safety and efficacy of influenza antiviral drug "Avigan Tablet" (generic name: favipiravir) in Japan for patients of COVID-19, a respiratory infection caused by the novel Coronavirus (SARS-CoV-2).


tangor

8:36 pm on Apr 5, 2020 (gmt 0)

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Nice catch! As this respiratory virus is so closely similar to "flu" there could be benefit for future use.

JorgeV

9:56 am on Apr 6, 2020 (gmt 0)

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The BCG vaccine seems to help.

In lot of countries, this vaccine is mandatory for kids, but needs to be renewed every 15 or 20 years. This might explain why kids are less impacted by the covid-19 (even if there are some cases of-course). So maybe a solution, is this vaccine, created 100 years ago.

lammert

11:35 am on Apr 6, 2020 (gmt 0)

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The idea behind this is that the BCG vaccine gives a non-specific boost to the immune system [sciencemag.org]. As with all potential medicines in the COVID-19 fight, the first research steps have already been set.

I am not convinced however of the link between BCG vaccine and protection against younger people against COVID-19. BCG has never been administered on a wide scale in the Netherlands but also here COVID-19 cases are mostly elderly people. Scanning the list of countries which use(d) BCG [en.wikipedia.org] (jump to Usage) in their mass vaccination campaigns, I cannot find an obvious correlation between the current severity of the COVID-19 spread and BCG use.

Mark_A

12:05 pm on Apr 9, 2020 (gmt 0)

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The idea of BCG being influential was an idea to explain regional differences, specifically that South Korea had an 100% BCG program and seemingly lower covid-19 infections, while many BCG programs in other countries harder hit by coronavirus were voluntary and in some cases not well supported. I think BCG is not yet proven as a factor.

There are differences of scale between South Korea Hong Kong Singapore epidemics, compared to Italy Spain France UK USA Iran. A key difference may be preparedness, because of past experiences with viruses, and strong early testing tracing and isolation programs.