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the employability of someone that took that action.I'm sure he's receiving lots of offers from companies/organizations that are anti-Trump.
the repercussions upon the outgoing employeeThis could be an interesting situation for case law, in terms of deletion of intellectual property (of Twitter) or possibly even theft (from Trump), depending on Twitter's ToS.
a misguided company might agree with this person's sentimentsI completely agree. However, during the past couple of years, we've seen so many misguided companies that are have put politics (or the personal values of the CEO) ahead of common business sense and had it come back to bite them. They don't seem to comprehend that not everyone shares their view, or that sharing their view on issue A doesn't necessarily mean sharing their views on all other issues.
It may seem funny, but if it was your account you'd be upset
not to mention obvious national security concerns...