Forum Moderators: open
Replace motion tweens with actionscripts. Ensure that all reused elements exist in only one place, as a "Symbol" in the Library. Avoid using the fancy-schmancy line effects (like the sketched line weights, splatters, etc.). Tweak your JPEG, sound settings and anything else in the "Publish settings" dialog that looks like it could affect file size.
From a social engineering point of view, use preloaders and have the movie load in sections while other sections are playing. (Load seconds 20-40 while it plays seconds 0-20.)
What else am I missing? There's got to be other tricks out there. :)