Significant is relevant, so don't be shy.
For me, $$,$$$ is more than chump change but $10K won't alter much in my life. Bills to pay . . Burn rate . . Etc.
Offers of $$$,$$$/$100K and up are a bit more of a challenge to walk away from . . but I recently had to say "no" to such an offer . . because it's just that good of a Web address. (It's already in development.)
After rejecting the overture I had a moment or two of thinking about my decision, but I moved on.
To follow that, last week I did have the unique pleasure - if you're into BDSM - of seeing a domain that I chose to drop subsequently sell at auction for >$2,500. (Things that make you/me go "Hmmmmmm . . ")
So, how's life treating you lately? Holding or folding? Standing firm or buckling at the knees? Recently say "no"? How'd ya feel?
Ever go back and try to regain of affection of a jilted domain lover? (Me? Never. That would be like admitting I was wrong, ya know? Me? Wrong? Whoa! :-/ )