The general theme of all the answers is, "Yes you can, but don't"
Ask yourself what is your favorite eCommerce site, or the most popular eCommerce site out there that has a .org domain name?
.com is the most recognizable domain extension, so don't buck the trend. Get creative with the domain name and you will be sure to find something, e.g., myfavoriteXYZ.com, greatXYZsales.com.
In the "dot com" era the consensus thinking was that domain names should be short and easy to remember (high recall value); that thinking is no longer prevalent (IMHO). If you want people to find you organically, then they will never need to remember the URL by typing it in directly.