Oh absolutely. Now that I'm pushing it. I stayed away from it for years even though I had legit, lucrative offers on an almost weekly basis. Too much work, I thought. Too much to keep up with. My idea these days is to try to minimize the time I spend behind this desk because it gets in the way of the fishing.
Circumstances have changed though. Adsense isn't what it was for me. It still pays the bills but I'd like a little more than that.
Your milage will probably vary but hey, what have you got to lose?
True,hmmm I guess you have to have a site that gets let's say 80k UU a day than maybe advertisers would come. As of now we do not have direct offers from them. We have to keep continue testing and see what would work best without AdSense. It's a shame that google it's like a monopoly in this business.
I get about 90k unique visitors a month and massive (Google says 100,000, but my adstats say 400,000) pageviews off those and direct advertisers work well for me. Also, nobody complains that I also have Adsense, plus another network (pay per impression) on the pages.
Your ad rates may be competitive to what G or other networks charge, though I have found that everybody seems to have a different idea as to what is reasonable and what is not. Most advertisers will want direct links, meaning you have to know how to use div tags and create text "boxes", but once you get some advertisers on your site, others in the niche will take notice and contact you directly.
I have found that it's definitely worth the effort, as those extra bucks pay for extra stuff.
Nothing comes close to AdSense, which is one reason they keep competitors at bay, but direct advertisers do add extra revenue, moreso than Adbrite or Kontera or any of those. A lot of advertisers do not want to deal with Adwords or use Adwords and want another route as well. And if you can develop a good relationship with them, they'll stick around and are a good back up if AdSense tanks. Worth the effort.