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I'm not sure what they use as their criteria. For me, it was probably my site design which they didn't like. I was getting 5000 uniques a day. But who knows, maybe they want busier sites these days, the Internet is always growing, I imagine there are always more publishers then advertisers.
Last time I applied to TribalFusion they told me to try back in 6 months. It was an auto-reply, the trick is to get a hold of a real live Sales Rep. I got accepted at Valueclick only after I managed to get the name and email of a Sales Rep and then I convinced him to let me in.
Go ahead and apply to all 3 at first. In fact, you could try a different tactic and switch the order. First try TribalFusion, with a nice clean website, with no ads on it yet. Maybe they didn't like my site because it already had so many ads up.
There is nothing wrong with applying. Just if you get turned down, wait awhile before reapplying or you might get blacklisted.
Casale Media is smaller then the other 2, so the fill% is not as good, the eCPM is also a bit lower. But, everything fluctuates, if you have all 3 you can rotate, if one company starts paying less then you rely on the other 2...
The major issue, however, is slow loading times for some of their ads. They'll keep a page from loading until the ad loads and sometimes that can take several minutes. Most users refresh the page but it's a real hassle. Tech support thinks it's an issue on our side but when we remove their code we have no problems whatsoever. Once their code is back up we'll experience a delay every so often.
I just started a thread on this very subject at [webmasterworld.com...] And the reason I finally decided to do something about the slow page load time was right after I included Direct Media Exchange ads on my page, the pages seemed to get even slower then normal and my page views per visitor dropped even more.
So I removed all ads and my page views per visitor doubled.
Right now I am working on slowly moving the ads back onto my website working with Casale Media, Google AdSense and Value Click, and sticking them on the very bottom of the page.
Check out the link if you are interested.
I also got some help involving an Ajax script, which I haven't tried yet.
However, I am going to do this very slowly, so I will be able to tell which company are the worst offenders, and also which type of ads, i.e. Pop ups and Intersitials.