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Recruiting affiliates can be extremely difficult and time-consuming. NEVER send bulk email to prospective affiliates; each recruitment email should be personalized and explain why the site is a good fit (don't say "your site is a great fit," but specific details about why the fit is good.
At least 50% of your email to prospective affiliates will never reach the affiliate; you'll be lucky to get responses from 2% of the emails you send. Thus, follow-up is crucial: phone calls, perhaps even a mailed letter (perhaps with samples of your work).
Given the low response rate, there is a HUGE temptation to use "bulk" strategies to recruit affiliates; they will not work, and will probably backfire (resulting in blacklisting and resentment).
[edited by: eljefe3 at 11:18 am (utc) on Oct. 17, 2007]