That is, if you're running a website, you have a setup where if visitors click an ad once, then they never see that ad again (using a cookie or something). I was originally thinking this would work to eliminate ads for regular visitors (that is, why show an ad if the visitor has never and probably will never click it anyway because they're simply not interested in that product), but you could also use it to serve a fresh ad once someone has clicked a previous ad. Mostly interested in the former, though. You'd have some text indicating that the visitor would never have to see an ad again if they click it once, etc. etc.
Would this work?
TIA