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Tamper protection prevents unwanted changes to security settings on devices. With this protection in place, customers can mitigate malware and threats that attempt to disable security protection features.
When a tampering attempt is detected on endpoints, an alert is raised in Microsoft Defender Security Center. Using the rich endpoint and detection response capabilities in Microsoft Defender ATP, security operations teams can investigate and resolve these attempts.
I fear a lot of the consumer grade AV software will be disrupted by this.