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With SP3 I've noticed no issues save for the fact that security center which I had disabled was reenabled by SP3. I'm fine with that as I know how to turn it off though non-savvy users may benefit by having it enabled.
Installing it also shortened the user-agent string sent by my IE browser -- It removed the terribly-long list of .NET version identifiers, reducing the user-agent string to about half its previous length.