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This update resolves a newly discovered, privately reported vulnerability in the Microsoft Malware Protection Engine....
An attacker who successfully exploited this vulnerability could take complete control of an affected system. An attacker could then install programs; view, change, or delete data; or create new accounts with full user rights.
We've had a few issues where Windows Defender didn't even detect, let alone clean older malware that was easily blocked and/or cleaned by Trend Micro PC-Cillin.
Windows Vista will disable Defender if it is installed on a new computer.