I like Chrome. I would probably use it as my main browser except that whenever it asks me to save a file, the dialog box is hidden. I have to click outside of where the dialog box should be in order to see it.
Even when I do that, sometimes it still doesn't render. It's only as I move the cursor back and forth over the box that it draws in the various buttons. Most often it still doesn't show the file and directory list until I change directories. It has been doing this forever, does it on both my computers (XP and Vista) and is the only app that does anything remotely close to that.
I have hardly any plug-ins (just Lastpass, but it did it before I had that running).