See my examples:
Settings: all languages/all countries/no synonyms
parkinson disease symptoms-> 6 combinations
parkinson disease-> 201 (max) combinations
parkinson-> 23 combinations only!
So, doing a solid and consistent keyword research is absolutely essential for a successful AdWords campaign - you all know. If we can't go from the general terms (e.g. "parkinson") to the more specific terms (e.g. "parkinson disease") we have a big problem.