I work in an industry with very few good content providers running AdSense, and the CTRs for content clicks are really bad (.1%, .2% CTR)--although for all I know those are normal rates for AdSense. I have this experience with multiple products and sites using AdWords so I don't think it's just my poor copywriting skills--my search CTR's are really very good.
I'm not worried about fraud with these abominable rates. But content displays outstrip my search displays by 5-1. If I turn off the content advertising, will it affect the number of impressions I get from search?