Just make sure to take care of all the other factors when doing this so that you don't spend unnecessarily:
- Research and include Negative keywords
- Tightly themed adgroups with generally no more than 20-50 keywords per adgroup
- Relevant landing pages with unique content, easy to navigate and transparent privacy policy
- Use of match types (Broad, Phrase, Exact)
- Proper geo-targeting if applicable
- More than one ad text, but not more than 2-3 running at a time per ad group.
- You might want to initially let Google optimize your ad rotation to display the one with the higher CTR more often and then rotate them evenly after you've established a decent CTR so you can conduct proper A/B tests on them
- Depending on the type of product or service you're offering, opt out of the search partners network so that you can more quickly identify problem areas that directly impact your quality score (According to Google, the search partner network does not impact QS). Rumor has it that Google plans to disclose performance separately for Google search traffic and Search partner traffic, but until then, you're probably better off opting out at the beginning till you have a chance to optimize things.
- If you want to get into the content network, be sure to create a separate campaign so you can manage it separately.
- As an alternative to boosting bids manually, you can also experiment with the advanced features of ad scheduling where you can choose to boost bids by a percentage. This is great if you want to do this in the short-term at the campaign level. If you want to boost bids at the adgroup or keyword level then this option is not ideal.
There are other things to look at but this is a good start to make sure that you don't bleed too much in the beginning and hurt your quality score in the process.
And without looking at things holistically within the system, it's easy to make false judgments or jump to the wrong conclusions.
Don't be shy to let me know if I ever run off topic or said differently provide an answer that is not very "relevant". :)