I've noticed some advertisers choose "All Languages" from the Campaign Settings. The presumed advantage must be that it will catch the foreigner who is searching in their native language but from a Google preference that is set to the language of the country in which the reside.
So, if a French woman residing in Germany conducts all her searches in German for business reasons, when the boss isn't looking she may do a search on "Gérard Depardieu" and not see your adword ad because you have not set your ad for All Languages.
But for a b2b ad, would you want your ad shown for all languages? Are the Language Settings of little value?
Or