I have three or four categories which are not directly related to my niche but bring in, at least according to the category section in the adsense panel, more revenue than impressions. These categories seem on paper to be very unrelated.
The best fit category shows around half the impressions but brings in around 25% revenue.
The above categories that bring in more revenue than impressions get a round 3% to 5% impressions, which means I am getting a staggering 30% of impressions from all the unrelated categories. I have decided to block them for now because I want Adsense to be showing ads only from the best fit category (and one or two other semi-related ones). This should give the ads the most chance of being clicked.
I have recently been targeted by impressions based ads because I've noticed I've been making around 25 to 30% of my revenue in the last month from impressions only, which is extremely high from a historical perspective. I normally get under 5% monthly revenue from impressions-based ads.
I wish I could block all non-related categories, but they restrict you to around 200 sub-categories.