Hi,
Just thought I could share what works "for me", in case it gives inspiration to others. Of-course all sites are different, and what works for one, will not work for another one.
What seems to work fine (for me):
- All Adsense's options activated (which is the default). I made tons of experimentation over the years, by disabling some options, but came to the conclusion that Adsense knows best.
- Async code.
- Set the Ad Balance slightly higher than the recommendation. The fill rate suggested, for a 100% earning, is around 45%, so I set it to 55%. I feel like it "gives a chance" to some ads to make it anyhow, and see if they can be profitable or not.
- On desktop, two ad slots only, one 728 x 90 on top middle, and one 300 x 600 on top right column (I tried on a left column, as suggested here, but I didn't see any impact, so, since the right column is better matching my page layout, I stayed with it).
- On desktop, I alternate Text-only and Display-only ads, in such a way that when the 728 x 90 is text-only, the 300 x 600 is display-only, and vice-versa. So I always have one text ad, and one display ad. I feel like it focus more the attention of visitors. Also, when it comes to have twice the same advertiser , it prevents from having twice the same image, or text.
- On mobile, two ad slots only, one Ad links on top, one 300 x 250 in the middle of the page.
- Use javascript to select which ad to display depending of the device' screen width.
- Get white listed with Ad block plus ( which means to serve text-only ads to ad block users, and "normal" ads to others).
What doesn't work (for me):
- Responsive code. I can't explain why, but during my experimentation responsive ads were always performing way less than fixed size ad slots.
- Bigger ad slots like 970 x 90, 300 x 1050.
- Smaller ad slots like 320 x 100 (on desktop) . I like the idea because it looked minimalist and simple, but it never worked.
- Two ad slots of 300 x 250 one above the other. I found it nice looking to have 2 x ad slots, instead of a 300 x 600, but it never gave good results.
- Having more than 2 ad slots. In the past, I had a third ad slot, but it earned very few, and as soon as I removed it, my earnings increased (more competition between advertisers?).
Hope it can help,