@MrSavage it was proposed above that ad blockers constitute 20 to 30% of all traffic. So let say 30% (I see 10 to 15% on my site, but I'm not in one of the high ad-block niches)
A quality link is pointed to your site, as a result there is gain in page-rank and an increase in rankings, so for arguments sake you get 1000 more searchers per month. A gain in rankings will drive more of the same traffic to the site, so of the 1000, 30% are ad-blocking, thus the net gain in non-ad-blockers is 700 more users. That is 700 more potential ad clickers. Yes there is a kind of tax, with 300 ad-blockers, but 700 is better than nothing or worse.
Note: 1000 is purely subjective, it could 100, 10 or 1M. The point is something is better than nothing.
IMHO, the bottom line is the only thing you can somewhat control is driving traffic to your site, as more ad-blockers are used, as cpc's drop, as mobile use increases, all this makes it more difficult to earn money. So you have no choice, add traffic, build better quality, create buzz, add links (naturally).
We work in a very competitive environment, with nearly no barriers to entry. The bar of success is being pushed higher and higher, those that can't compete will fail, and those that have created real sites with real quality content, will come out on top. And yes, I think my site is the best, and you probably think yours is too, but nobody give a rat's ass of what you are I think. It is the user's opinions that count. Pissing off users by flipping them the bird is probably not the best strategy to get them to embrace and love your site.
Let me add, that bombarding users with useless, invasive and annoying ads is not a solution either. Ironically, it is most often the webmasters that overload their sites with ads, that end up blocking users with ad blockers.
This how I see it, a webmaster creates a mediocre site, makes some money at first (probably spends it, as opposed to reinvesting it), as competitors enter the niche users find better websites, revenues decline. Webmasters says "I need to increase revenue, ads = revenue, more ads = more revenue", he ads more ads, remaining users become more annoyed and start searching for better sites, the few committed users that remain block ads. Webmasters sees further decline in revenue, he blames the ad blockers,so he blocks the ad blockers. Who's left? A trickle. Now what? Change ad network, add affiliate links...
The root cause of the problem was mediocre content, not too few ads or ad blockers. I have seen this with people I have worked with in the past. The strategy does not lead to success.