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(Replace a 336x280 with a 125x125 and see what happens)
Not all ad blocks hold the same number of text ads.
Because not all advertisers create ads for all display ad sizes.
Depends on if you're talking about text ads or display ads. For text ads, the advertiser just creates an ad, and that's it.
If that is not the case and there is more ad inventory on the smaller ad sizes I should consider changing my site.
That is the reason I chose to use the larger sizes, not that I thought that bigger ads were better, but that it would increase the competition for my adspace and drive up eCPM rates.