It comes with a "direct traffic" spike in analytics. Bot and other non-human traffic will appear in analytics as direct traffic, as soon as this happens (a direct traffic spike) CTR in the adsense interface is half what it was in my case. It seems bots force the ads to load or reload. I see direct traffic fluctuations in analytics from 10 visits a day to 2000 visits a day, then back to 10 again.
At least earnings will stay the same.
Also screen resolutions, bounce rate, time on site and other stats don't add up any more when this happens, it makes most of the adsense and analytics reports worthless.