Google claims that sitewide ads pay more than CPC ads (in theory), however in my experience they actually drag earnings down. I them on my site now for the past two months or so, and the result - steadily dwindling CTR. If you visit a site, and the majority of ads are all from the same advertiser, you will be much more likely to be blind to the ads altogether.
Has anyone had experience with removing or blocking these ads, and things getting better?