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For me it would be great if I could add the adsense JS for a few days, while hiding the ads (for example by setting google_ad_height=0;). This would bring in the spider to crawl most of my pages. Then, when I make the ads visible, they will all show the properly targeted ads already.
I think this would be a great feature for large sites with many pages like mine.
Regarding those charity ads, I may point out that indeed they may apear offensive to local websites, where the visitor will have no comprehension of these american specific charities.
I'd rather see public servicwe ads which are truly public with international apeal. There are plenty of worldwide cahrities, take your pick from wildlife preservation to help-the-children style charities.