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Now Im thinking, if my subdomains are talking different topics, will it hurt the smart pricing value of my existing subdomains?
On the other hand, if all my subdomains are on similar topics, will it have better smart pricing value? As the domain is highly relevant to the topic.
The best thing for you is to use channels and monitor each topic's performance over a month, then pull the ads off the really bad performing sections and see how that affects your earnings.