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Adwords in adsense?
Split testing is a simple idea and with channels in adsense you can split test that.
With adwords you will need different landing pages and a way of tracking which ad produced which sale or lack of sale.
e.g. target keyword is the same but you change the title on each ad. Then after a week you check the stats to see which had the highest clickthrough.
I presume this is possible some how?