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Just make sure you backup your entire site first. The corrections made using Find-and-Replace can't be changed easily or quickly.
I really can't stress the backup enough. I know too many people that have lost a great deal of work and created lots or problems and extra work for themselves because they didn't backup their site before making sitewide changes using the find-and-replace function!
You may want to try changing one folder at a time, just so you can keep an eye out for problems that you don't know exist yet.