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Above 80% the file size started getting quite a bit larger. Below 80% I saw more problems with the sky and white walls.
HTH - Bea
Which type of graphics software are you using?
Which filetype are you looking to optimize? GIF, JPG, PNG?
What is the purpose of the graphics file, and what sort of problems have you run into in the past.
All of this information will greatly increase the chance of others helping you.
For photographic images, JPEG is best. JPEG will leave artifacts on text and screenshots, so GIF/PNG is best for these kinds of images. If you end up choosing GIF for non-photographic images, and the image doesn't have transparency or animation, then an optimized PNG will usually give you a smaller file.
Up until Photoshop 8, I often thought Fireworks had a small edge over the compression algorithms in ImageReady. But not now -- ImageReady today really cooks for me! And this is coming from a guy who is fanatical about image size. Up to Photoshop 8, I often hand tweaked the color look-up tables in a gif, just to eleminate any extra colors the eye didn't truly need.