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Would it also cause a some sort of URL unfriendliness?
Google doesn't treat /page.html#anchor as different URL than /page.html. It might be possible that keywords after # mark matter a little, but in Google links database everything after # is stripped.
I'm sure about this after checking with site: command one of my sites which uses #anchor links extensively. The site is old and completely crawled, links with # are showing in the source of my page in Google cache, but site: command shows only pure URLs.
Some other badly written bots do however have problems with them and actually send requests with them. But these are usually the ones which are hostile bots (email harvesters, site copiers) that you don't want visiting anyway.
Hard to believe they can't detect and fix this bug, but it's been going on for at least a year, as recently as yesterday.