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I've put some lab handouts on my Web site, as PDF files that were generated by Microsoft Word from Word documents.
I just realized that the PDF isn't generated by Word, but by Mac OS X. It's an option in the standard print dialog in all applications.
I took a look at the "Document Properties" in Adobe Reader. The title, subject, author and keywords fields are all blank. So Google isn't getting the title from any of those, at least in my case.
As I mentioned before, the title is formatted in the "Heading 1" style. It's also the very first "paragraph" in the document. I don't know which is more important.