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See [hotwired.lycos.com...] for a good article on web colors.
Of couse, that is the web in general. I would guess that most of the people here have higher color resolution.
Case in point: I recently found out that one machine on our network was running 16 colours (yes, 16). My lovely intranet looked a total mess and I was close to a heart attack - but the operator hadn't even realised there was anything wrong...
While I'd never rely on people having the latest and greatest system for functionality issues, I'm undecided as far as cosmetics go...
That's often what I figure... if you're using an incredibly old browser or a 256 color monitor, the vast majority of websites are going to look screwed up in some way. I doubt any specific page will have a grudge held against it for not looking good on a 12 inch/256 color monitor with a machine running Netscape 3.0.
OTOH... if you design your page (or an alternate version w/ browser sniffer) so that it looks *really good* on a set-up like that, you will probably earn the undying gratitude and loyalty of the fractional percentage of surfers visiting your site with 'antique' machines!
A friend of mine who is reasonably savvy got into this situation after a windows reinstall, and is perfectly happy running 640x400 on a 19 inch monitor... I offered to set it to a higher resolution but he really does like it the way it is...
<shrug>
I design in 32-bit color, but check it at 16 bit before I say it's a go. I want to be sure I give the leading edge people something to appreciate if I can.
Unfortunately, changing color depth takes a re-boot, whereas only changing screen resolution does not. Sometimes I begrudge the time it takes for the 2 re-boots, and I skip the double check at 16 bit. BAAAD habit.