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Having higher RPM disks will make a difference as well. The comparison between 5400 RPM and 7200 RPM is enough to choose 7200 over 5400. I don't know about the 10K RPM SATAs. Usually a more imporatnt fact will be the Cache that it will have on board, and the connection type. If you're after ultimate speed, try Fibre Channel,Ultra-320 SCSI or Serial Attached SCSI. SCSI also has a very good track record for reliability and durability compared to consumer-level ATA and SATA.